- 0.1 Synthroid (Levothyroxine) makes up for deficiency of thyroid hormones
- 0.2 Description of Synthroid (Levothyroxine)
- 0.3 The main functions and distinctive features of the Synthroid (Levothyroxine)
- 0.4 The positive effects of buying and taking Synthroid (Levothyroxine)
- 0.5 Side effects of Synthroid (Levothyroxine)
- 0.6 Synthroid (Levothyroxine) Dosage
- 0.7 Availability Synthroid (Levothyroxine) for purchase
- 0.8 How to buy Synthroid (Levothyroxine) over the Internet?
- 0.9 General characteristics of Synthroid (Levothyroxine)
- 1 Types of hypothyroidism and the causes of the disease
- 1.1 Symptoms of reducing thyroid hormones in the blood (hypothyroidism)
- 1.2 Pathological changes at the level of each system separately
- 1.3 How is the concentration in the blood of hormones regulated?
- 1.4 Features of hypothyroidism in childhood
- 1.5 Pregnancy in hypothyroidism
- 1.6 Treatment of hypothyroidism
- 1.7 How to evaluate the effectiveness of treatment of hypothyroidism?
- 1.8 Hormone treatment, benefits and risks?
Synthroid (Levothyroxine) makes up for deficiency of thyroid hormones
Description of Synthroid (Levothyroxine)
Synthroid (Levothyroxine) is a thyroid hormone, or rather a synthetic version of the natural hormone, which is called tetraiodothyronine (T4). This drug is one of the most common thyroid hormones from those that are presented today in the consumer market. The most famous brand of this product is Synthroid (Levothyroxine). In the consumer market, it came in 1955 thanks to the Flint Laboratory. In fact, today almost all variants of this hormone are called Synthroid, even if in fact they were released under a different brand.
The main functions and distinctive features of the Synthroid (Levothyroxine)
Synthroid is a synthetic thyroid hormone. Like all similar products, it is designed to regulate metabolic processes. If we talk about medical practice, first of all Synthroid is used to treat hypothyroidism.
This disease is associated with the inability of the thyroid gland to produce enough hormones. In the future, this disease leads to an increase in body weight, a decrease in vital energy and a change in the structure of hair and skin.
When a person starts taking Synthroid, he makes up for the lack of a hormone that is not able to produce the thyroid gland. Therefore, T4 is a kind of backup copy of T3. Therefore, in most diseases of the thyroid gland, the patient will be appointed Synthroid (Levothyroxine).
But athletes use this drug to burn excess fat. Typically, Synthroid (Levothyroxine) is presented in cycles to reduce body weight. Although much more often athletes choose T3, which by its pharmacological characteristics is four times stronger than Synthroid. But we should not forget about the possible consequences of legargia and a decrease in vital energy.
The fact is that thyroid hormones actively feed ATP and can deplete your energy supplies, especially if you follow a strict diet. Such a process can lead to the destruction of the previously acquired muscle relief. Athletes who are about to start buying and taking Synthroid (Levothyroxine) should clearly understand that now there will be much more thyroid hormone in their bodies than is necessary, so you need to be prepared for certain consequences.
Therefore, if you do not want to lose the already acquired muscle relief, do not buy and take Synthroid (Levothyroxine) without anabolic steroids. However, even if hormonal anabolics are introduced into your course, the presence of a strict diet can cause loss of muscle mass. Therefore, before starting such a course, you should carefully study the question of balancing hormones and nutrients in the body.
The positive effects of buying and taking Synthroid (Levothyroxine)
The positive effects of buying and taking Synthroid (Levothyroxine) are very obvious. If a person is sick with hypothyroidism and his thyroid gland does not produce enough hormones, he starts buying and taking Synthroid (Levothyroxine) and replenishes what is not done naturally. From a medical point of view, this all the positive effects of this drug ends.
If we talk about receiving Synthroid (Levothyroxine) for sporting purposes, then here positive effects lie on the surface. If an athlete tries to lose weight and lose fatty layer, then with the introduction of additional hormones in his course, similar to those produced by the thyroid gland, he can get rid of extra pounds much faster. Due to the fact that this drug has the ability to transform into T3, metabolic processes will be significantly activated, which means that fat burning will occur more intensively.
However, to achieve a positive result, you must necessarily diet. After all, if you eat more calories than you spend, you will never be able to get rid of unwanted pounds. That is, you should clearly understand that as a separate unit Synthroid does not help you get rid of fatty deposits, but if you join this drug to a competently composed diet, you will simply have an amazing result.
Quite often this tool is combined in one course with various beta-2 stimulants, for example Clenbuterol. This greatly increases the effect of burning fatty deposits.
Side effects of Synthroid (Levothyroxine)
Synthroid (Levothyroxine) may actually have some side effects, but in general this drug is considered quite safe. In most cases, side effects occur due to a significant overdose. So, the side effects that are possible on the Synthroid course include:
– Increased sweating;
If we talk about severe drug abuse and significant overdoses, then the side effects begin to be more dangerous.
Such manifestations include:
– Heart failure;
– Shock states;
In the event of a prolonged overdose, a fatal outcome may occur.
Synthroid (Levothyroxine) Dosage
Regardless of the reasons for buying and using this drug is taken orally. If it is taken to treat hypothyroidism, the average dosage is 100 to 150 milligrams of active ingredient per day. Dosage may increase slightly if a person has an impressive body weight, but at the first stage of treatment it will be the same for patients with any weight.
If we are talking about burning fat, then at the initial stage the daily dose will be about 50 milligrams of active substance per day. As necessary, this dose can be increased, but it needs to be done gradually. If we are talking about short-term use, then every 3 days you can increase the dosage by 25 milligrams until you reach the maximum threshold. If you take the drug for a long time (about 12 to 16 weeks), then every 2 to 3 weeks you need to increase the dosage by 12.5 – 25 milligrams.
However, remember that you should not take more than 150-200 milligrams of active ingredient per day.
Availability Synthroid (Levothyroxine) for purchase
Synthroid (Levothyroxine) is widely available both on the legal and the black consumer market. It can also be purchased through research chemical laboratories that create this substance in liquid form for various experiments.
It should be noted that this product is rarely forged and, most importantly, it has a very reasonable price. Today, the most common way to buy Synthroid (Levothyroxine) for sports purposes is to order the drug through research laboratories. The fact is that illegal distributors do not always have it in stock, since they prefer a more powerful version of T3.
How to buy Synthroid (Levothyroxine) over the Internet?
Today you have many different ways to buy Synthroid (Levothyroxine).
You can do this both legally and through illegal distributors. However, you should remember that if you are in the United States and want to buy Synthroid (Levothyroxine) without a medical prescription, then this will be equated with a violation of the law. It should be noted that each country has different views on this issue, so before you make a similar transaction, carefully study the legislation of the place in which you are currently located.
Due to the fact that very often the purchase of such drugs is associated with a variety of different issues, when searching for various effective means for weight loss, we recommend that you visit our partner’s Online Pharmacy.
Here you will be offered a wide range of quality products that can be purchased without medical prescriptions and legal risks.
General characteristics of Synthroid (Levothyroxine)
Synthroid (Levothyroxine) is a synthetic analogue of the thyroid hormone, but in terms of its characteristics it can not even compare with T3. Many experts argue that, regardless of the purpose of using the best result, you can achieve if you take T3. However, some users note the perfect result after the course of Synthroid. Therefore, it is best to try both these drugs at different times and to choose the one that is most suitable for you.
Types of hypothyroidism and the causes of the disease
The thyroid gland is an endocrine organ, that is, it secretes hormones directly into the blood. Like all other endocrine organs obeys the higher organs of the central level of the endocrine system.
Hypothalamus is the main regulatory body that oversees the work of the organs of internal secretion. Regulation is carried out through the development of liberins and statins.
Liberians – stimulate the pituitary gland.
Statins – depress the pituitary gland.
The pituitary gland is also the central organ that regulates the activity of peripheral endocrine glands. It stands in second place after the hypothalamus and is subject to its influence.
Classification of pathological phenomena occurring in the thyroid gland is made taking into account the primary cause, which disrupts the gland.
Primary hypothyroidism is considered to be a disease that is directly related to the pathology of the thyroid gland.
1. Congenital disturbances in the formation and development of the organ;
2. Genetic defects;
3. Inflammatory, autoimmune processes in the thyroid gland;
4. After treatment with drugs that inhibit the synthesis of thyroid hormones (Mercazolil);
5. Deficiency of iodine intake in the body (endemic goiter).
Secondary hypothyroidism is the hypothyroidism that developed as a result of damage to the pituitary gland.
The pituitary gland ceases to produce TTG (a hormone stimulating the thyroid gland).
1. Congenital maldevelopment of the pituitary gland;
2. Brain trauma with damage to the pituitary gland;
3. Massive bleeding;
4. Tumors of the pituitary gland (chromophobic adenoma);
5. Neuroinfection (brain).
Tertiary hypothyroidism occurs when initially there are irregularities in the hypothalamus.
The causes that cause disorders at this level are the same as in secondary hypothyroidism.
Symptoms of reducing thyroid hormones in the blood (hypothyroidism)
Thyroid hormones play an important role in the metabolism.
Therefore, the symptoms of the disease are associated with a shortage of thyroid hormones.
Mechanisms of development of symptoms of the disease
To understand the importance of thyroid hormones for the function of organs and systems, we give some examples of metabolic disorders:
1. On the part of protein metabolism, a decrease in the synthesis of important protein compounds is noted. Protein, as is known, is a “building” material for cells, tissues and organs.
The absence of protein leads to a delay in the development of intensively dividing tissues:
– Gastrointestinal tract (GIT) – manifests itself in the form of digestive disorders, constipation, flatulence (increased gas formation), etc.
– Albumins – proteins that support oncotic blood pressure. In other words, keep the liquid part of the blood in the bloodstream. The absence of such leads to the onset of edema of the subcutaneous fatty tissue.
– Reduction of muscle activity manifests itself in the form of weakness, lethargy.
– Activity of the central nervous system is falling, sluggishness, apathy, insomnia.
2. Violations of carbohydrate metabolism. Reduces the use of glucose for energy needs of the body. The synthesis of adenosine triphosphate (ATP), necessary for all energy processes occurring in the body, is reduced. Also, heat production decreases, which leads to a decrease in body temperature.
3. Changes in fat metabolism are observed in increasing cholesterol, and other fat fractions that increase the risk of atherosclerosis and obesity.
The main initial signs of the disease are general symptoms seemingly inconspicuous at first glance, the totality of which leads to the thought of the appearance of any pathology. The initial period has an erased character, and a little current.
4. Weakened memory;
5. Constipation is due to a decrease in the sensitivity of the smooth muscle fibers of the gastrointestinal tract to the stimulating impulses emanating from the nervous system. The amount and intensity of peristaltic contractions of the intestine decrease, which leads to a delay in fecal masses.
6. Decrease: libido (sexual desire), potency (in men). It occurs as a result of a decrease in the activity of metabolic processes at the level of sex hormones, which are also under the stimulating effect of thyroid hormones.
7. Violation of the menstrual cycle.
Already at first at a general inspection it is possible to suspect an endocrine pathology of a thyroid gland:
1. The face is large and puffy;
2. The swelling of the eyelids.
The above symptoms are explained by a violation of the water-salt balance in the body. The content of sodium salts increases, followed by water in the tissues.
3. Eyes sunk, eye slits narrowed. The tone of the muscles lifting the upper eyelid and the circular muscles of the eyes falls.
4. Dry dry skin on palpation (due to decreased blood flow in small vessels).
The patient complains about:
– Feeling of constant cold;
– Breakage and hair loss;
– Weakness, brittle nails.
Pathological changes at the level of each system separately
Cardiovascular system (CVS)
– The slowing down of metabolic processes leads to the establishment of bradycardia (a decrease in the number of cardiac contractions, less than 60 beats / min.).
– As a result of relaxation of the heart muscles, the borders of the heart expand.
Gastrointestinal tract (GIT)
– There is a decrease in appetite. It is explained by a decrease in the acidity of gastric juice.
– Constipation occurs due to weakness of the motor muscles of the intestine.
– Macroglossia – increase and pastose of the tongue, often with the imprint of the teeth.
The central nervous system (CNS)
The central nervous system is the most volatile system. As a result of reducing carbohydrate metabolism, little energy is released. Slow down metabolic processes at the level of the central nervous system, impaired transmission of nerve impulses.
The most pronounced symptoms are:
– Apathy, lethargy;
– Insomnia at night and drowsiness during the day;
– Decreased intellect, memory;
– Decreased reflexes.
Very often, various motor disorders are revealed, which are manifested in the fact that:
– Slow down movements.
– The time needed to reduce muscle fibers increases, as well as to relax them.
– The duration of tendon reflexes slows down. It is due to the slow relaxation of the muscles.
All of the above changes are due to the fact that the metabolism slows down, and little energy is generated necessary for the work of the muscular system. Against the backdrop of treatment with thyroid hormones, contraction of muscle fibers and reflex movements come back to normal.
How is the concentration in the blood of hormones regulated?
In the hypothalamus and pituitary gland there are departments responsible for the regulation of individual endocrine glands. All of them are located in close proximity to each other, so with various injuries, tumors and other pathological processes in these areas, the work of several departments will inevitably be disrupted at once.
Because of the reduced amount of thyroid hormones (thyroxine, triiodothyronine), the secretion of thyrotropin-releasing hormone TRH by the hypothalamus is reflexively increased. This hormone has a stimulating effect on the synthesis of not only thyroid hormones, but also on the synthesis of prolactin – a hormone necessary for lactation in women during pregnancy.
The excessive amount of prolactin disrupts menstrual function in women:
Dysmenorrhea – a violation of the periodicity of the appearance of the menstrual cycle. It manifests itself in the form of delayed onset, or vice versa, too frequent occurrence of the menstrual cycle.
Amenorrhea is the absence of a menstrual cycle for at least six months in a row.Infertility – is rare in the most severe cases with untreated hypothyroidism.
Features of hypothyroidism in childhood
If the hypothyroidism appears from birth as a result of genetic disorders, or other anomalies, then during the childhood period, lags are noticeable:
1. In the physical development
– The child is gaining weight poorly.
– The child lags behind in growth.
– The child late starts to hold a head, sit, walk.
– The child is delayed ossification of the skeleton.
– The baby is late to close the fontanelles.
2. In mental development
– There is a delay in the development of speech skills.
– At school age: decrease in memory, intellectual abilities.
3. In sexual development
– The appearance of secondary sexual characteristics is late:
Axis hair under the bosom.
– Late menstrual cycle is established, and other changes.
Early detection of this pathology allows timely start appropriate treatment and avoid such developmental disorders.
Pregnancy in hypothyroidism
With untreated hypothyroidism, the appearance of pregnancy is a rare occurrence. Most often, pregnancy occurs during the intake of medicines aimed at treating the deficiency of thyroid hormones.
Despite the fact that pregnancy can occur against a background of hypothyroidism, children are born on time and are quite healthy. This phenomenon is explained by the fact that the thyroid hormones do not penetrate the placental barrier and have absolutely no effect on the development of the fetus.
Treatment of hypothyroidism in pregnant women does not differ from that of non-pregnant women. The only thing that can be noted is a slight increase in the doses of drugs taken.
If during pregnancy, do not take appropriate treatment, then the risk of complications associated with the course of pregnancy increases:
– Spontaneous abortions in 1-2 trimesters.
– Miscarriages in the 3rd trimester.
– Premature birth.
These complications do not occur in all cases, and depend on the severity of the course of the disease and the concomitant complications of other organs and systems. Their appearance is due to the slowing down of all kinds of metabolism in a pregnant woman, and as a consequence the insufficiency of nutrient intake, for the development of the fetus.
Treatment of hypothyroidism
Regardless of the clinical form of the disease, substitution therapy is prescribed. This means that the patient will take continuously small doses of drugs that contain synthetic analogues of thyroid hormones.When hypothyroidism occurs in childhood, treatment immediately after diagnosis, in order to avoid complications associated with impaired growth and development of the child.
The use of beta-blockers.
Older patients, as well as other persons suffering from cardiac dysfunction should take in combination with hormonal drugs, drugs that prevent, reduce the stimulating effect of thyroid hormones on the work of the heart. These drugs include a group of beta-adrenoblockers (metoprolol, propranolol synonyms – obzidan, inderal, anaprilin).
In the cardiac muscle there are beta-adrenergic receptors, the excitation of which has a stimulating effect on the work of the heart. Thyroid hormones have a stimulating effect on these receptors, thus increasing the strength and heart rate. With ischemic heart disease, a sharp increase in the concentration of thyroid hormones in the blood can cause significant damage from the heart. To prevent this, beta-blockers that reduce the sensitivity of the beta-receptor of the heart are taken, and thus prevent the risk of complications from cardiac activity.
Compliance with diet.
Patients with hypothyroidism are very important to receive adequate nutrition. The diet should contain all nutritional ingredients in sufficient and easily digestible form. It is recommended to eat food in a boiled form. Exclude from the diet fried, fatty foods.
1. Products rich in cholesterol:
– Animal fats (butter, sour cream, lard, etc.).
– The egg.
2. Products containing a large amount of salt (to avoid increased swelling of the tissues):
– Salted fish (herring, ramming).
Pickles (salted cucumbers, tomatoes).
Appointed fortifying complexes of vitamins A, B and group B.In case of anemia, preparations containing iron (sorbifer, totem), vitamin B12 are given.
How to evaluate the effectiveness of treatment of hypothyroidism?
To fully assess the effectiveness of the treatment, to raise the question of the need to increase or decrease the dosage of drugs, rely on a set of physical indicators in combination with laboratory tests.
1. Disappearance of clinical symptoms.
2. Recovering the patient’s ability to work.
3. Acceleration of physical development (height, weight) in children.
4. Normalization of the cardiovascular system and pulse (normal 60-80 beats / min).
5. Restoration of normal laboratory parameters of thyroid hormones:
– Level of TTG;
– level T3;
– T4 level.
Hormone treatment, benefits and risks?
With the beginning of the use of hormone therapy in medicine, many people began to regard with concern the hormonal drugs. And the negative attitude towards hormones extends to the therapy of absolutely all diseases. During this time, a number of myths about the dangers of hormonal drugs.
Myth number 1. “Against the background of taking hormones, a lot of excess weight is being taken.” Indeed, in some cases, glucocorticosteroids, sex hormones can lead to excess weight. But this happens when the type of hormonal preparation is incorrectly selected, the method of its administration and dosage, and also in the absence of monitoring of laboratory indicators against the background of hormone therapy. In the treatment of hypothyroidism, thyroid hormone preparations, on the contrary, contribute to the normalization of weight.
Myth number 2. “Hormones are addictive and, after their withdrawal, the course of the disease is aggravated.” Yes, against the background of a sharp discontinuation of taking hormonal drugs there is withdrawal syndrome, which can lead not only to the deterioration of the disease, but even to the death of the patient. The withdrawal syndrome does not arise if the dose is gradually reduced before the cessation. When hypothyroidism, which requires not lifelong, but temporary hormone replacement therapy, also before the abolition gradually reduce the dose of the drug under the control of the level of TSH, T3 and T4 in the blood.
Myth number 3. “All hormonal drugs have a lot of side effects.” Everyone, even a plant and vitamin preparation, has the risk of developing side effects. Thyroid hormones in principle do not cause side effects, if an adequate (not exceeded) dose of the drug is prescribed. Overdose of thyroid hormones can lead to the development of symptoms of hyperthyroidism. Therefore, hormonal therapy of hypothyroidism is carried out under the control of thyroid hormone levels in the blood.
Myth number 4. “Indications for hormone therapy are only extremely severe conditions.” Although hormones are used for diseases with severe clinical manifestations and for vital signs, hormone therapy can be recommended in situations where the patient does not have specific symptoms of the disease or the disease does not pose a threat to the life of the patient (for example, oral contraceptives (birth control pills), hormonal Ointments for skin diseases and so on). Thyroid hormones are strongly recommended for subclinical and transient hypothyroidism, the main indicators of which are the indicators of laboratory studies.
Myth number 5. “Drugs of hormones can be used irregularly.” All hormonal drugs must be used at certain times of the day, strictly by the hour. This is necessary because, in the body, all hormones are released at the set time of the day and in the strictly necessary dose, regulating all the processes in the body. So, glucocorticosteroids are recommended to be applied in the morning immediately after awakening, on an empty stomach, and oral contraceptives – at any time of the day. Thyroid hormones are best taken once in the morning, on an empty stomach, 30 minutes before meals. But the main condition for all hormones is reception strictly by the hour, every day. Irregular reception of any hormones (today I drink, tomorrow I do not drink) is not permissible under any circumstances, because, firstly, it can lead to withdrawal syndrome, and secondly, does not give a positive therapeutic result.
Myth number 6. “The use of hormonal drugs for the treatment of children leads to irreversible consequences.” In childhood, there are also a lot of diseases that require hormonal therapy, and hormones are prescribed for life indications. The risk of side effects from taking hormonal drugs is much lower than from those diseases that require this type of treatment. In the case of congenital hypothyroidism, irreversible consequences result from the lack of treatment with thyroid hormones, rather than the medication itself. Cretinism is a serious illness that has irreversible changes for the health and life of the child.
Myth number 7. “Hormonal drugs can be replaced with other types of medicines or traditional medicine.” In the case of hypothyroidism, diabetes mellitus and other endocrine diseases, hormone therapy can not be replaced with anything. These diseases are caused by the disruption of the production of vital hormones and, unfortunately, at this stage, treatment can be directed only at replacing its own hormones artificially synthesized. No grass, lotion and “panacea pill” can restore the function of endocrine glands and normalize the level of hormones. As for hypothyroidism, self-medication and time missed for experiments can lead to negative consequences related to absolutely all metabolism, systems and organs, mental state.
So, we can identify the main principles of substitution therapy with thyroid hormones:
1. Any deficiency of thyroid hormones (even subclinical form) requires hormone replacement therapy.
2. The choice of doses and the determination of the duration of the course of therapy should be determined individually, according to the level of thyroid hormones in the patient’s blood.
3. Treatment with thyroid hormones should be carried out only under the control of the level of TTG, T3, T4 and autoimmune antibodies to the thyroid gland.
4. Childhood and pregnancy is not a contraindication, but it proves to be a mandatory indication for the treatment of hypothyroidism with drugs of thyroid hormones.
5. Hormonal therapy should be timely, prolonged, regular, continuous and controlled.
6. Traditional medicine in the treatment of hypothyroidism can only be used in parallel to thyroid hormones, and not instead of them.
7. The use of thyroid hormones with the right approach is safe. The risk of development of irreversible consequences of hypothyroidism is much higher than from the intake of hormonal drugs.
Do not self-medicate, life-threatening!