- 1 What is Avodart (Dutasteride) used for?
- 2 Dutasteride mechanism of action
- 3 How to buy Dutasteride in UK?
- 4 Avodart (Dutasteride) indications
- 5 Avodart (Dutasteride) dosage
- 6 Avodart side effects
- 7 Dutasteride (Avodart) 0.5 mg cost
- 8 Where to buy Dutasteride (Avodart) online? Cheap Avodart
- 9 Dutasteride (Avodart) results and reviews
What is Avodart (Dutasteride) used for?
Avodart (Dutasteride) is a drug used to treat benign prostate adenomas.
In addition, Avodart is used in medical practice to prevent the pathological process. During the period of therapy, the patient must regularly undergo a rectal digital examination to prevent the development of a cancerous degeneration of a benign neoplasm.
The mechanism of action of the drug Avodart (Dutasteride) is based on the suppression of the activity of 5o-reductase isoenzymes type 1 and 2, which are responsible for the transformation of the male sex hormone into DHT (5-dihydrotestosterone). This hormone is the main hormone in men, which participates in the hyperplasia of the endocrine part of the prostate gland.
Medication Avodart (Dutasteride) helps eliminate or prevent the development of benign prostatic hyperplasia (BPH). Avodart helps to normalize the natural process of urination, reduces the risk of acute urine retention, reduces the size of the prostate.
Taking this medication is a conservative treatment if the patient refuses to undergo surgery or this procedure is impossible for some reason.
Dutasteride mechanism of action
Avodart is a hormone preparation containing dutasteride, the main enzyme that blocks the transformation of testosterone into dihydrotestosterone (DHT). DHT – androgen, which promotes benign proliferation (hyperplasia) of the prostate.
The maximum therapeutic effect (decrease in concentrations of dihydrotestosterone) depends on the amount of Dutasteride taken and is observed during the first 1-2 weeks after the start of therapy.
After this period, the average serum concentration of the active substance is reduced by 85% (after the first 7 days of therapy) and 90% (within 2 weeks).
With a single dose of Avodart (Dutasteride) with a dosage of 0.5 mg, the gelatin capsule shell disintegrates under the action of esterases and the active component begins to be absorbed by the villi in the small intestine. When injected into the systemic circulation, the drug compound reaches its maximum performance in plasma after 1–3 hours. Bioavailability is 60%. Eating slows down the absorption rate and reduces the bioavailability of the drug Avodart (Dutasteride).
Due to the high degree of binding to plasma proteins (about 99.5%), the active substance penetrates into the structure of tissues.
Distribution ranges from 300 to 500 liters. The drug Avodart (Dutasteride) is transformed in the liver cells under the action of the cytochrome p450 system and the isoenzyme CYP450-3A2. As a result, 3 large and 2 small metabolic products are formed.
Avodart is excreted with feces 24 hours after administration at 1-15.5% in its original form. Through the kidneys, the body excretes about 1% of the substance. With repeated use of a therapeutic dose of Avodart (Dutasteride), its half-life is 21-35 days. At the same time, Dutasteride can show up at laboratory tests in serum for 4-6 months after treatment.
How to buy Dutasteride in UK?
Online purchase of the drug Dutasteride with delivery to the UK is convenient and very popular. This purchase has a lot of advantages compared with the purchase of drugs in urban pharmacies. That is why the number of buyers of online pharmacies is growing every day.
You can visit the online pharmacy at any time of the day, even at night, and spend as many hours as you like. You do not have to spend time on the road back and forth or run from one pharmacy to another in search of the drug Dutasteride in the UK.
Confidentiality. When you buy Dutasteride from an online pharmacy in the UK, no one sees your face, so you can buy intimate medicines without confusion or embarrassment.
Regardless of their geographical location (UK, Canada or Australia), any Internet user can purchase Dutasteride (Avodart) from anywhere in the world and for this he does not need to buy a plane ticket, you just need to place an order sitting at a computer in his house.
When you fill in the order form of the drug Dutasteride, it is better not to hurry and do not be distracted. Check all of the data you provided several times: your address in the UK, the method of delivery and payment, the recipient’s last name, and so on.
Avodart (Dutasteride) indications
Indications for use of Dutasteride.
Avodart (Dutasteride) medication helps eliminate or prevent the development of benign prostatic hyperplasia. The drug Avodart helps to normalize the natural process of urination, reduces the risk of acute urine retention, reduces the size of the prostate.
Dutasteride (Avodart) is a conservative treatment if surgery for any reason is impossible.
Avodart (Dutasteride) dosage
For adult men, it is recommended to take 1 capsule of 0.5 mg per day. Dosage form of the drug can not be chewed. Mechanical damage to the gelatinous capsule shell violates the speed and completeness of absorption.
It is recommended to use Avodart 0.5 mg capsules before meals.
Therapeutic effect of Dutasteride comes quickly, but the duration of therapy should not be less than 6 months. This time is necessary for an objective assessment of the effect of the drug on the state of the prostate.
Avodart side effects
Undesirable effects are due to the anatomy of each person individually and they manifest themselves in all different ways.
Rarely is the allergic response of the body to the drug: itching, redness, angioedema.
Rarely manifested reaction from the skin and subcutaneous fat tissue: baldness or vice versa increase in hair growth.
There are depressive conditions, testicular edema and pain very rarely.
Dutasteride (Avodart) 0.5 mg cost
The drug is sold for 30 or 90 capsules in a package of 0.5 mg each. The price for Avodart depends on the place of purchase, it does not differ in low cost, like other hormonal drugs, 30 pieces cost about $36.06, 90 – $75.73 and above.
Below is a table with the Avodart (Dutasteride) average prices at online pharmacies:
|0,5 mg x 10 pills||$20|
|0,5 mg x 30 pills||$51|
|0,5 mg x 60 pills||$89|
|0,5 mg x 120 pills||$146|
|0,5 mg x 360 pills||$389|
Where to buy Dutasteride (Avodart) online? Cheap Avodart
Online shopping in online pharmacies is not only convenient, but also very profitable. You can buy Dutasteride (Avodart) at prices much cheaper than in pharmacies of your city.
For many buyers who are just starting to get acquainted with the basics of buying drugs online, everything seems complicated, incomprehensible and even frightening. In fact, shopping at online pharmacies in the United States or Canada with delivery to many cities in the world is very simple and convenient.
For those who have never bought cheap Dutasteride (Avodart) in the US online pharmacies, but really want to start doing this, we have prepared this article. Online shopping in the US is easy, fun and very cheap!
First of all, in order to make the purchase of the drug Dutasteride (Avodart) online, you must have a personal payment card to pay for purchases. American or Canadian online pharmacies are free to accept Visa, Mastercard. Many stores also accept payment through the PayPal payment system and other alternative payment methods for the drug Dutasteride.
In the US and Canada, there is an incredible number of online pharmacies where you can cheaply buy Dutasteride (Avodart) 0.5 mg. On this page there is an example of our partner’s popular and reliable online store, from which you can start purchasing Dutasteride (the link-banner of this store is slightly higher). But you can, of course, make purchases of the drug Dutasteride in any other online pharmacies – here you are in no way limited.
The principle of placing orders for Avodart (Dutasteride) 0.5 mg is approximately the same in all US stores:
- initial registration (your email and password);
- fill in the delivery address of Dutasteride;
- filling in your billing data (your payment card);
- the choice of dosage of Dutasteride (0.5 mg), the number of packages and payment for the purchase;
- waiting for sending / delivery of the order to the warehouse.
After that, as a rule, within a few days, the store sends the drug Dutasteride (Avodart) 0.5 mg to your address (or warehouse).
Detailed step-by-step instructions on how to place orders for Dutasteride in specific American or Canadian stores can be viewed on their websites. But, once again we repeat that the process of ordering drugs is the same for the absolute majority of stores.
Dutasteride (Avodart) results and reviews
Nikolay, 45 years old.
I am treated by Avodart for three months, I still do not notice any changes. But it is noticeably reduced attraction to his wife, maybe age affects? But erectile function also disrupted. The doctor says that you need to wait, after six months everything will be fine.
Michael, 39 years old.
I studied the instructions for Avodart application, prices, analogs, I think I will not accept. Many side effects, and judging by the reviews on the sites, the effect is not so much.
Oleg, 41 years old.
I took this drug, I was pleased: urination improved, even the mood rose! Now I forget about the problems, but the doctor advises not to stop the course of treatment.