The search for ways to restore the erectile function of physicians and traditional healers has been practiced since time immemorial, but scientific medicine made a real breakthrough in the early 90s of the twentieth century, when accidentally, in the course of clinical trials of a drug for the treatment of coronary heart disease, scientists from the American pharmaceutical company Pfizer received a stunning secondary Effect.
Which one? We believe you already know the answer to this question – strengthening the erection! The drug was called Viagra, and the active substance, which gave billions of dollars to the developers, is called sildenafil.
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Sildenafil Citrate (Viagra)
Active Ingredient: Sildenafil Citrate
Viagra is indicated for the treatment of erectile dysfunction in men. Viagra is a phosphodiesterase type 5 (PDE5) inhibitor. It works by helping to increase blood flow into the penis during sexual stimulation. This helps you to achieve and maintain an erection.
Talk about drugs that affect the erection, of course, should be built around sildenafil. Yes, we will get acquainted with other medicines, some of which are derivatives of sildenafil, while others have nothing to do with it, but in the treatment of erectile dysfunction, sildenafil helped to make a qualitative breakthrough.
Mechanism of action
How it works? Sildenafil is a highly selective inhibitor of the enzyme phosphodiesterase – 5. By suppressing the activity of this enzyme, the drug dramatically increases blood circulation in the vessels of the penis and pelvic organs. Increased blood flow promotes the filling of blood with cavernous bodies, there is an erection. It is also important that the erection after taking sildenafil occurs only in the presence of sexual arousal.
Sildenafil citrate is taken 1-2 hours before the alleged sexual contact. The therapeutic concentration of sildenafil in the blood is reached in 30-120 minutes, so this interval is quite sufficient and there is no sense to exceed it.
What you should pay attention to? Fatty food slows the absorption of sildenafil, and in this case, the effect may occur later – in 2-3 hours, and this should be taken into account. The optimal dose is selected individually. The standard dosage is 50 mg, however, someone will need to double it, and someone will have 25 mg.
Important! The maximum daily dose is 100 milligrams, it can not be exceeded!
Another extremely important moment, from which sometimes depends not only the health of a man, but also his life. Sildenafil can not be taken concurrently with nitrates (used to treat IHD), because it can lead to a sharp uncontrolled drop in blood pressure and death!
A combination of sildenafil and calcium channel blockers, beta-blockers and hypoglycemic oral medications is potentially dangerous for men. In these cases, there is also a risk of developing uncontrolled hypotension.
It is better to abstain from taking the drug if there are heart diseases, severe arterial hypertension or hypotension, arrhythmias. In the first six months after myocardial infarction, sildenafil should be taken with great caution (and it is better to refuse it at this time). Also, the drug is not recommended for patients with myeloma, leukemia, sickle-cell anemia and in the presence of deformation (anatomical) of the penis.
About the testimony, I believe, it is not necessary to speak separately, because the drug is prescribed with only one purpose – to eliminate erectile dysfunction.
Derivatives of sildenafil
We pass to other preparations. To begin, let us become acquainted with the derivatives of sildenafil, which include vardenafil (Levitra) and tadalafil (Cialis). The mechanism of action of these drugs is exactly the same as that described above. The same is true for contraindications, but what is different is the dosing regimen.
Vardenafil, which is manufactured by the German pharmaceutical company Bayer, is prescribed in a dosage of 10 mg. If necessary, the dosage can be increased or decreased by half, and the maximum daily dose should not exceed 20 mg. The same dosages should be adhered to when taking Cialis, which is manufactured by the American pharmaceutical company Eli Lilly.
According to clinical studies, Cialis and Levitra have a longer action (up to 36 hours vs. 6 hours for Viagra), and the effect is faster.
In clinical trials, it has been found that Viagra is assisted by 82% of men, Levitra is 85%, and Cialis is 92%. It is not necessary to take these figures as a guide to action when choosing a particular drug, but they definitely say a lot about the effectiveness of the sildenafil group.
As for other drugs that you can meet on the shelves of pharmacies (Genagra, Eregra, etc.), they are all only generics of the above drugs, that is, they are produced by pharmaceutical companies that bought a patent from their developers for their production. There are no differences from the original drugs, the only difference is that they are cheaper, the effectiveness may be lower, but there are no doubts in the presence of contraindications.
Other tablets for restoring erectile function. Have you ever thought about why sildenafil and its derivatives are so popular, although they are quite expensive? The answer is simple – this is the only effective solution to this problem.
Homeopathic medicines (Impaza, erectin, etc.) are offered as alternative ways of treating the dysfunction of the pharmaceutical company. Should I expect an effect from them? Perhaps, after six months of regular daily intake, you will feel some improvement, but the reviews of many patients indicate that the money spent on this (also expensive) treatment was thrown out – the effect is either not present, or it disappears immediately after discontinuation.
As for the supplements (BAA), which include preparations such as Yohimbe and the Golden Horse, then it is enough to read the instructions to these “products” in which it is said that they are “fortifying preparations”, and everything becomes clear. However, if this tool helps someone, then it has a full right to exist – the choice is yours.